Signal transduction of umami taste: insights from knockout mice.
نویسندگان
چکیده
Minqing Rong1,2, Wei He1,2, Keiko Yasumatsu3, Zaza Kokrashvili1, Cristian A. Perez1, Bedrich Mosinger1, Yuzo Ninomiya3, Robert F. Margolskee1,2 and Sami Damak1,4 1Department of Physiology and Biophysics, Howard Hughes Medical Institute, the Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA,2 Howard Hughes Medical Institute, the Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA, 3Section of Oral Neuroscience, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan and 4Nestlé Research Center, Vers-Chez-les-Blanc, CH-1000 Lausanne, Switzerland
منابع مشابه
Sarco/Endoplasmic Reticulum Ca2+-ATPases (SERCA) Contribute to GPCR-Mediated Taste Perception
The sense of taste is important for providing animals with valuable information about the qualities of food, such as nutritional or harmful nature. Mammals, including humans, can recognize at least five primary taste qualities: sweet, umami (savory), bitter, sour, and salty. Recent studies have identified molecules and mechanisms underlying the initial steps of tastant-triggered molecular event...
متن کاملMultiple receptors underlie glutamate taste responses in mice.
l-Glutamate is known to elicit a unique taste, umami, that is distinct from the tastes of sweet, salty, sour, and bitter. Recent molecular studies have identified several candidate receptors for umami in taste cells, such as the heterodimer T1R1/T1R3 and brain-expressed and taste-expressed type 1 and 4 metabotropic glutamate receptors (brain-mGluR1, brain-mGluR4, taste-mGluR1, and taste-mGluR4)...
متن کاملLrmp/Jaw1 is Expressed in Sweet, Bitter, and Umami Receptor–Expressing Cells
Inositol 1,4,5-triphosphate-mediated calcium (IP3-Ca2+) signal cascade is an essential process in sweet, bitter, and umami taste signal transduction. Although the main components of this cascade have been identified, the candidate regulators of them in taste tissues are still unclear. In an effort to identify genes involved in taste signal transduction, we found that a gene encoding lymphoid-re...
متن کاملAjcn27462i 743..746
L-Glutamate confers cognitive discrimination for umami taste (delicious or savory) and dietary information to the brain through the activation of G protein–coupled receptors in specialized taste receptor cells of the tongue. The taste heterologous receptor T1R1 plus T1R3 is not sufficient to detect umami taste in mice. The lack of T1R3 diminished but did not abolish nerve and behavioral respons...
متن کاملDownstream signaling effectors for umami taste.
Monosodium glutamate (MSG) elicits a unique taste called umami. A characteristic feature of umami taste is its potentiation by 5′ribonucleotides (primarily GMP and IMP), which also have an umami taste of their own. Based on recent molecular studies, two putative umami receptors have been identified: a truncated variant of the metabotropic glutamate receptor mGluR4 (taste-mGluR4) (Chaudhari et a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical senses
دوره 30 Suppl 1 شماره
صفحات -
تاریخ انتشار 2005